SR-121463A 185913-79-5
价格:8600元/公斤 含量:99% 包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro
[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 3-
(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in THF to
yield the disulfonate (III). The condensation of (III) with 5-ethoxyindolin-2-one
(IV) by means of tBu-OK in THF affords the spiro compound (V), which is deprotected
with HCl in methanol to afford the spiranic alcohol (VI). The oxidation of (VI) with
pyridinium chlorochromate (PCC) over Al2O3 provides the spiranic cyclohexanone (VII),
which is treated with 2-chloroethanol (VIII) and Ms-OH in toluene to give the ketal
(IX). The reaction of (IX) with zinc borohydride and trimethylsilyl chloride in ethyl
ether/dichloromethane yields the 2-chloroethoxy derivative (X), which is condensed
with 4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of
tBu-OK in THF to afford the adduct (XII). Finally, the target compound is obtained by
condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by
treatment with fumaric acid.
2-FDCK CAS号：111982-50-4 Diclazepam CAS号：2894-68-0
SR-121463A CAS; 185913-79-5 Lexaurin 1812-30-2
MXE Methoxetamine CAS号：1239943-76-0 Delorazepam 2894-67-9
Ald-52 3270-02-8 oxazepam 604-75-1
Phencyclidine CAS号：77-10-1 clonazepam 1622-61-3
PCP hydrochloride CAS号：956-90-1 Flupyrazopon 31352-82-6
MDMB-CHMICA 1715016-78-6 oniria 36735-22-5
3-MeO-PCP 72242-03-6
4-MeO-PCP 91164-58-8
3-MMC 1246816-62-5
4-AcO-DMT 92292-84-7
4-AcO-MET 1445751-40-5
4-CEC 22198-75-0
4-HO-MiPT 77872-43-6
5-MEO-DMT 1019-45-0
6-APB 286834-84-2
6-APB 286834-85-3
6-APDB 1281872-58-9
6-APT 3160-20-1
Gastro-Caine 99232-07-2
PENTYLONE (HYDROCHLORIDE) 17763-01-8
HEXEN 18410-62-3
BK-EBDP 8492312-32-2
2-FMA 1017176-48-5
3-HO-PCP 79787-43-2
3-HO-PCE
3-MeO-PCE 1364933-80-1
DCK 4631-27-0
5F-ADB 1715016-75-3
SR-121463A 185913-79-5